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Studies also strongly suggest that an overactive mTOR pathway drives DAMD pathology, with dysregulation in the AMPK and SIRT1/PGC-1 pathways also contributing to metabolic alterations [63,64,65]

Metabolic reprogramming Throughout the life of an organism, the immune system continually senses and responds to environmental threats, which is a relatively energy-consuming process

Then, the filtered datasets were compared to the Omit LaccID condition, using a P -value cutoff of 0.01 and an FDR of 5% for monocultures and 10% for cocultures (Supplementary Table 2 and Supplementary Figs

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