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Also observed in the obese mice were increased mRNA levels of Xbp-1, Grp78 and CHOP, as these are indicators of endoplasmic reticulum stress, and are believed to be activated by obesity

In contrast, limiting the consumption of dietary thiols, including those naturally derived from the microbiota, extended lifespan

Cell 2017;169:126375.e14

Ethics statement The animal study was reviewed and approved by the Animal Ethics Committee, College of Medicine & Health Sciences, UAE University

Therefore, the goal of next-generation mitochondrial-targeted therapies is not to eliminate mtROS entirely, but to modulate it back within a physiological window, thereby restoring redox homeostasis without causing reductive stress

doi: 10.3168/jds.2012-6005 22 BrazC