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FIGURE 2 The structural hallmark of IDD is the progressive dehydration of the NP mainly due to the gradual loss of proteoglycans within the ECM (Vadal et al., 2015

It manifests by the failure to induce transcription of progesterone-target genes despite adequate hormonal bioavailability [36]

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Nijhout HF, Reed MC, Ulrich CM: Multiple and diverse mechanisms of homeostasis in a complex metabolic network