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Journal of Orthopaedic Research , 24(7), 1421-1432.

These data are preliminary and derive from bioinformatics analyses, but they form the basis for further in vivo studies

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For context, the recommended dietary allowance for copper in adults is approximately 0.9 mg per day, and copper clearance from tissue through standard metabolic pathways appears efficient in animal models

4 1 C metabolism and anti-tumor therapy As discussed earlier, enzymes and metabolites involved in the synthesis and utilization of 1 C units are critical drivers of tumorigenesis and progression, either through their canonical enzymatic activities or through non-canonical functions