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It is often triggered by: Hormonal changes Pregnancy Birth control pills Sun exposure Related: Types of Melasma and Best Treatments for Each

Hepatitis B immune globulin and hepatitis B vaccine Vaccine Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases

Zhang W, Liu Y, Liao Y, Zhu C, Zou Z

However, when produced in excess, ROS can overwhelm cellular antioxidant defenses, leading to oxidative stress and the disruption of essential biomolecules, including nucleic acids, proteins, and membrane lipids

Nature 550 , 360365 (2017)

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