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This hypothesis was grounded in the observations that alcohol-elicited place conditioning is prevented by DA receptor antagonists [15, 16], that caffeine exerts, through an antagonistic action on A 2A adenosine receptors (A 2A R) [17], a direct negative control on neuronal firing of DA cells in the posterior ventral tegmental area (pVTA) [18], and that caffeine administration prior to alcohol also prevents its DA-dependent [19] ability to increase the expression of phosphorylated Extracellular signal Regulated Kinase (pERK) in the shell of the nucleus accumbens (AcbSh) [13, 20]

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Ishijima T, Nakajima K (2021) Inflammatory cytokines TNF, IL-1, and IL-6 are induced in endotoxin-stimulated microglia through different signaling cascades

10.1177/20503121231209088 218 YangH.LiuC.YuanF.LiF

From urban homes to modern cafs, kanji is once again finding its place in everyday life

WS and XW collected the literature, and WS prepared the original draft