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For instance, in one 1960s study of intravenous NAD+ for addiction, patients who received a fast IV drip experienced immediate headache and shortness of breath, whereas those given the same dose at a slower drip rate (under ~35 drops/min) had no distress

Guidance Note 8

Medical Conditions Management: Autoimmune diseases like multiple sclerosis benefit from supportive therapy involving regular B12 administration, bolstering immune defenses

do not use intravenously

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[1] If a rash or generalized itching develops, the injection should be halted and the patient evaluated, as it could be a prodrome of a more serious reaction