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This ultimately leads to an elevated CD4+/CD8+ ratio (176)

While the exact cause is unknown, inflammation, hormonal imbalances, blood sugar imbalances, bacteria, and environmental toxins are factors that have been shown to contribute to the development and progression of endometriosis

The mechanism of this effect is via upregulating the SOCS-2 protein which in turn inhibits the JAK1-STAT5 signal transduction pathway of the GHR (371)