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Here, we summarize the mechanisms and dynamics of DNA methylation alterations in neurological diseases, such as immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, Rett syndrome (RTT), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimers disease (AD), Parkinsons disease (PD), Huntingtons disease (HD), fragile X syndrome (FXS), and epilepsy

Autophagy is a sequential process that is primarily regulated by autophagy-related genes (ATGs) and various adaptor/receptor proteins, including sequestosome 1 (SQSTM1/p62), optineurin (OPTN), NBR1, NDP52, NIX, and FUNDC1 53

Failure of the intricate PLOOH repair system is a principle cause of ferroptotic cell death

In summary, ferritinophagy results in abnormal iron accumulation and eventually induces ferroptotic death