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Analogous to its role in adipocytes, GPR81 activation in cancer cells decreases intracellular cAMP and suppresses proteinkinase A (PKA) activity, thereby modulating lipid remodeling (55,56)

However, certain microsomal isoforms were only slightly or not at all altered (Rosa et al., 2010)

Non-alcoholic fatty liver disease in patients with morbid obesity: the gut microbiota axis as a potential pathophysiology mechanism

Therefore, a strategy that concurrently modulates metabolic pathways and disrupts intercellular communication represents a potential synthetic lethal approach, providing a novel direction for the systematic targeting of tumors and the improvement of therapeutic efficacy [372]

Lancet 395 , 470473 (2020)

Glutamine promotes the generation of B10(+) cells via the mTOR/GSK3 pathway