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The gene localized to chromosome 22q13qter, and a number of mutations have been identified

10.1371/journal.pone.0248103 71 LautatzisM

Alveolar capillary damage can precipitate diffuse alveolar hemorrhage (DAH), potentially progressing to ARDS (197, 198)

Thus, the pro-fibrotic ingredients such as TGF1, oxidative stress, and ROCK are indicative of penile fibrotic process, and inhibiting these factors by anti-fibrotic agents such as iNOS, NO, and cGMP could ameliorate or block this process