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In the process of physiological ageing, both systemic and tissue-specific systems show functional downfalls, which, when projected to the brain, translate into weakening defence and metabolic strain resulting from age-dependent declines of the cardio-vascular system and overall decreases in metabolism

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a MHC complex comprising one or more entities (a-b-P) n , wherein a and b together form a functional MHC protein capable of binding a antigenic peptide P, and wherein (a-b-P) is the MHC-peptide complex formed when the antigenic peptide P binds to the functional MHC protein, said MHC complex optionally further comprising a multimerization domain comprising a carrier molecule and/or a scaffold

The tBid promotes the activation of mitochondrial outer membrane permeabilization (MOMP) effector proteins BAX and BAK, which further trigger the recruitment of other caspases to perform apoptosis [148]

Avoid alkaline pH conditions and prolonged exposure to elevated temperatures that promote peptide degradation

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