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Topical applications may cause skin irritation in sensitive individuals, with contact dermatitis reported in 3-8% of users

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

They should not be treated as if they were all included in one HPLC purity result

Kielian T, Esen N, Liu S, Phulwani NK, Syed MM, Phillips N et al (2007) Minocycline modulates neuroinflammation independently of its antimicrobial activity in Staphylococcus aureus-Induced brain abscess

doi: 10.1515/rns.2011.028 Summary Keywords Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis, neurodegenerative diseases, antioxidant biomarkers, bidirectional Mendelian randomization study Citation Zhang Q, Li Q, Zhao H, Shu M, Luo M, Li Y, Ding Y, Shi S, Cheng X and Niu Q (2023) Neurodegenerative disease and antioxidant biomarkers: A bidirectional Mendelian randomization study

Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the Omega class glutathione S-transferases