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10.1007/s12015-009-9069-x 99 HuangH.KimH

They are sometimes discussed together because both have been studied in tissue-repair research models, but the published literature treats them as separate research subjects

Although little is known, it was demonstrated that zinc(II) deficiency increased the level of NO and superoxide anion by the inhibition of the N -methyl-d-aspartate receptor (NMDAR) [45] As described on PC12 cells, NMDAR activation leads to an increase in cytoplasmic calcium levels and, thus, to increased ROS [66]

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FIGURE 9 Discussion Unfavorable environmental stimulation can alter cellular redox homeostasis, which causes the excessive generation of ROS

May 20 2020;12(5)doi:10.3390/nu12051488 Valls RM, Pedret A, Calderon-Perez L, et al