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This downward migration of ORS cells in human hair follicles agrees with observations in rodents 20 , where especially in whiskers an average downwards speed of ORS cells was estimated to be around 4 m/h 45

Under hypoxic conditions, HIF-1 stabilization promotes CD39/CD73 expression, leading to increased adenosine production

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doi:10.3389/fphys.2021.606931 Cappola AR, Desai AS, Medici M, et al

Through a distinct mechanism, choline uptake and PC synthesis regulate IL-1 production mediated by NLRP3 inflammasome activation (69) ( Figure 3 )