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Noteworthy, NTZ-200-induced reductions of liver enzymes reached closer levels to those observed with either NAC or 4-PBA

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Cyclosporine, though potent, requires vigilance for nephrotoxicity and hypertension, whereas apremilast offers a safer hepatic profile

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Synergistic effects between drugs are rare and have led to the need for innovative approaches to optimize therapy regimens [172]

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