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Summary: Evidence linking vitamin B12 deficiency directly to white or grey hair is limited, with hair greying predominantly determined by genetics and ageing rather than nutritional factors

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Tet3, the most highly expressed TET in the brain, is activity-dependent in primary cortical neurons [53]

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Importantly, severe immune-mediated toxicities characteristic for ICI have not been documented for DCV, which makes these therapies particularly attractive for the adjuvant setting and for combination strategies in patients who have already received multiple lines of systemic treatment and allows a prolonged vaccination schedule [33, 37, 40]

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