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Unfortunately, recent studies have reported global emerging resistance to azole antifungals in clinical and environmental isolates (Rhodes et al., 2022) ( Supplementary File 1 )

10.1096/fj.11-184697 FASEB J

This is probably due to the differing levels of susceptibility of different brain regions to OS

6.2 Therapeutic implications and challenges Despite the clinical correlations between FA dysmetabolism and GA severity, mechanistic insights remain fragmented, with most studies limited to biomarker associations rather than causal validation