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Studies over the past decade have emphasized HIF-1 as the central regulator of tumor cell survival, proliferation, angiogenesis, and metastasis under graded oxygen tension (Schofield and Ratcliffe, 2004)

doi: 10.1073/pnas.0500367102

The EM maps of helical tubules have been deposited in the EM Data Bank with the accession codes EMD-68805 for class I and EMD-68806 for class II, respectively