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A placebo-controlled study conducted in Iran involved 30 ulcerative colitis patients who were given placebo, 25 mg, or 50 mg saffron twice daily for eight weeks

doi: 10.1016/j.jbc.2022.102829 138 SahooB.GoyalR.DuttaS.JoshiP.SanyalK

Notably, we observed a general downregulation of metabolites in treated cells, with a higher number of differentially expressed metabolites at 12 weeks compared to 8 weeks