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Ethics statement The studies involving humans were approved by Ethics Committee of West China Second University Hospital, Sichuan University

Second, additive effect risks where two compounds affecting the same system (like glucose metabolism) can stack their effects beyond safe levels

The absorption of vitamin B12 depends on a protein called intrinsic factor, which is produced in the stomach

Currently, there is no established link between standard collagen supplementation and worsening of fatty liver disease, but equally, there is insufficient evidence to confirm beneficial effects on liver health in humans

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Finally, several reviews [147, 153] have synthesized this body of work, emphasizing how mitochondrial damage and mtDNA release create a vicious cycle: oxidative stress damages mtDNA, increasing its release, which then sustains inflammation and exacerbates amyloid and tau pathology