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10.1016/j.yexcr.2008.03.012 27 CollaE.JensenP

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SPan-1, a serum biomarker that has shown promise in detecting PDAC, sometimes demonstrates higher sensitivity than CA19-9, though it is not as widely utilized in clinical practice due to limited clinical validation, concerns about sensitivity and specificity, lack of standardization, and preference for more established biomarkers like CA19-9 [24]