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Conversely, cytokines such as IL-4, IL-13, and macrophage colony-stimulating factor (M-CSF) drive polarization toward the M2 phenotype, which secretes anti-inflammatory factors including IL-4, IL-10, and IL-13 (35)

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In SCLC, more than other malignancies, the standard of care is based on clinical demonstration of efficacy, and less on a mechanistic understanding of why certain treatments work better than others

glutathione sepharose beads ge healthcare Glutathione High Capacity Magnetic Agarose Beads (1:1 suspension in a 30% ethanol solution) Used in GST pull A virulence protein activates SERK4

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This complex subsequently activates caspase 1 (CASP1), which cleaves pro-IL1B, pro-IL18, and GSDMD

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