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A history of cardiac symptoms, a family history concerning for cardiac dysrhythmias, or abnormal physical examination or electrocardiography findings should prompt a more in-depth evaluation for heart disease

Some researchers combine it with KPV to address both the immune overreaction and the tissue damage simultaneously

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The analogous mutation of the TRAF6 binding motif within CD40, which was included as a control, also resulted in a loss of TRAF6 interaction (Supplementary Fig