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What is PT-141 (bremelanotide) and how does it work for men PT-141 is a melanocortin receptor agonist that enhances sexual function through brain pathways

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Lavinsky, Increase in retinal ganglion cells susceptibility to elevated intraocular pressure and impairment of their endogenous neuroprotective mechanism by age

In an alternative embodiment, the ability of a test compound to modulate the activity of a biomarker of interest (e.g., one or more targets listed in table 1 and/or table 2) can be determined as described above for cell-based assays, e.g., by determining the ability of a test compound to modulate the activity of a polypeptide that acts downstream of the polypeptide

10.1002/9780470123041.ch2 120 FukaiT.Ushio-FukaiM

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