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Growing evidence supports the potential effectiveness of curcumin combined with various chemotherapeutic agents, including Lenvatinib, Doxorubicin, Rapamycin, Paclitaxel, and Cisplatin, in treating diverse cancers such as breast, liver, colon, oral, and osteosarcoma [317, 372,373,374,375,376,377]

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Interestingly, these effects closely resembled those of imipramine, a tricyclic antidepressant drug [32, 33]

Unfortunately, as reviewed by van der Wielen and co-authors (75), most studies analyzing the expression of amino acid transporters were performed at the transcriptional level, not ensuring the expression of the functional protein and not allowing the evaluation of the cellular localization of these receptors

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