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2.2 Mood-stabilizers 2.2.1 Lithium The role of PKC in the pathophysiology of bipolar disorder was suggested in 1994 by Manji and colleagues after observing that chronic lithium use has PKC-dependent transcriptional and posttranscriptional effects involving long-term neuroplasticity and cellular response

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Besondere Bedeutung hat hier eine australische Arbeit mit 509 Patienten mit Behandlungsresistenz und Clozapintherapie [20]

A limitation inherent to all in vitro experiments is that our results may not reflect in vivo biologic behavior in dogs experiencing clinical ITZ-associated hepatotoxicity

doi: 10.1002/JLB.4RI0820-535R 112 NagaoAKobayashiMKoyasuSChowCCTHaradaH

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