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We further investigated whether the attenuated transactivation activity (Fig

Consequently, the targeted inhibition of GOT1, in conjunction with its upstream and downstream pathways, or the combined inhibition of the major metabolic pathways of glutamine, has emerged as a promising novel strategy to overcome metabolic therapy resistance

A recent genomic analysis of A and B clones encompassing 1128 genomes shows that clade A1 likely emerged as a clone from within A2, and due to ectopic genomic exchange that clade A2 HAI represents a continuum between clade B and clade A1, substantiating evidence for hybrid clones among the population in a direction towards clade A1 [71]

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doi:10.1371/journal.pone.0135268