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3.3 Molecular mechanisms of supraspinatus atrophy Supraspinatus atrophy in chronic rotator cuff tears (RCTs) results from disrupted protein homeostasis, neuromuscular impairment, inflammation, mitochondrial dysfunction, oxidative stress, and circadian rhythm dysregulation (Wan et al., 2022)

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The lack of monitoring means we cannot determine from existing clinical trial data whether semaglutide causes clinically significant b12 deficiency in typical patients

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