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Both lactate and its agonist, DHBA, induced a biphasic modulation in neuronal excitability, inducing reduced excitability at lower concentrations (lactate at 5 mM and DHBA at 0.56 mM), while higher concentrations (lactate at 30 mM and DHBA at 3.1 mM) increased firing frequencies

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(169) showed diabetic animal models administered berberine activates the Nrf2 pathway and decreases OxS

doi: 10.1186/s11658-021-00271-y 41 WuYKramHGemptJLiesche-StarneckerFWuWSchlegelJ