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Physical basis of cognitive alterations in alzheimer's disease.Synapse loss is the major correlate of cognitive impairment

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Specifically, the following key terms were used to generate the literature search for this review paper: Menopause, oxidative stress, antioxidants, estrogen, free radicals, herbal antioxidants, pharmacotherapy, hormonal therapy, phytoestrogens, osteoporosis, cardiovascular disease, and vasomotor disturbances

doi:10.1007/s10815-013-0029-7 Miyashita-Ishiwata M, El Sabeh M, Reschke LD, et al

Similarly to what was observed for CYS4- OE, the overexpression of YAK1 , the homolog of DYRK1A in S