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We have shown that our previously reported potent and selective NSD2 degrader, UNC8732, is metabolized enzymatically and the corresponding aldehyde species effectively recruits FBXO22 to promote ternary complex formation and subsequent degradation of NSD2 (Fig

Group 1 metabotropic glutamate receptors in neurological and psychiatric diseases: mechanisms and prospective

This advanced formula helps neutralize free radicals that can contribute to signs of aging while supporting healthy hair, skin, and nails through antioxidant support