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In dermal fibroblasts, GHK-Cu reduces TNF-alpha-induced secretion of IL-6, a major positive regulator of fibrinogen synthesis and inflammatory responses

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That might explain why having more visceral fat raises your risk of having cardiovascular disease

Phase Reta escalation 1 Weeks 5-8 Retatrutide 4 mg/week Cagrilintide Not started Notes Continue retatrutide alone

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Biochemical monitoring reveals no significant alterations in copper metabolism or systemic inflammatory markers, suggesting that topical GHK-Cu application maintains localized effects without systemic implications