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NLRP3 inflammasome connects lipid metabolism and inflammation because it is activated by crystalline cholesterol and oxLDL in plaques of AS, making it a possible player in the development of AS

The expansion of the necrotic core and the disruption of the plaque are largely determined by the accelerated number of apoptotic cells and phagocytic clearance defect

VEGF-A, Vascular Endothelial Growth Factor A

4.11 Regulatory networks of small RNAs in adipose metabolism MicroRNA-mediated regulation of gene expression occurs through binding to partially complementary sequences primarily in the 3 untranslated regions (3 UTRs) of target messenger RNAs, though binding can also occur in 5 UTRs and coding regions

She explains that menopausal women often show an increase of antioxidant capacity as well as lower glutathione levels along with high levels of oxidative damage. According to Tennant, this rise in antioxidant capacity may be compensatorya protective response as the body ramps up defenses to counteract mounting oxidative stress.Since glutathione levels decrease while oxidative stress increases, its reasonable to consider supplementing with glutathione or NAC, alongside lifestyle interventions like exercise, diet, sleep, stress management, and possibly hormone replacement therapy, Tennant says