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In plants, Glu can be principally synthesized via glutamine synthetase (GS)/Glu synthase (also known as Gln--ketoglutarate aminotransferase, GOGAT) cycle in the chloroplasts of photosynthetic tissue or non-photosynthetic tissue plastids and Glu dehydrogenase (GDH) in the mitochondria or cytoplasm

At low hydrogen peroxide concentrations and in the presence of suitable organic electron donors, compound I can be reduced by one-electron addition leading to the formation of compound II (a formal Fe 4+ state) which can cause enzyme inactivation

USA 100 , 1429714302 (2003)

In vitro toxicity assay HepG2 (ATCC, HB-8065) cells were maintained in Dulbeccos modified Eagle medium (Gibco, Cat #11965092) supplemented with 10% fetal bovine serum (FBS) and 1% penicillin/streptomycin

The PI3K/AKT/mTOR signaling pathway is a highly conserved signal transduction pathway in eukaryotic cells that stimulates cell survival, cell progression, and cell cycle events, and any malfunction of this signaling pathway can prompt to tumor development (230)

Its expression is directly driven by Foxp3 and is also influenced by retinoic acid [77]