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ALOX12, for example, promotes TP53-dependent iron apoptosis in specific cancer cells (61)

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Furthermore, the application of advanced tools such as single-cell multi-omics, spatial transcriptomics, lineage tracing, and organoid models will be crucial in unraveling resistance dynamics and guiding precision medicine

Resveratrol administration also increases the sensitivity of oral squamous cell carcinoma to cetuximab by decreasing the protein expression of uPAR, which inhibits the signaling molecule ERK1/2 downstream of EGFR [828]

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4, panel B) who, however, at baseline had a significantly lower AUC HIE than the hyperinsulinemic subjects (Fig