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For example, the tumor suppressor p53 could sensitize cells to ferroptosis by repressing the expression of SLC7A11 (Fig

The induction of tumor suppressor agents that act and stimulate apoptosis, such as initiator caspases (8 and 9), and effector caspase (3), p38, p53 and JNK1/2, and suppression of the expression or activity of apoptosis inhibitors such as Survivin and Bcl-2 have been discussed in various cellular studies (Agarwal et al., 2013)

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The in vivo passage was responsible for the modification in key phase-variable genes

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