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In March 2026, Roche reported that the Phase 2 ZUPREME-1 trial produced mean body-weight reductions of up to 10.7% at week 42 versus 1.7% with placebo under the reported analysis

Becker S, Schweinhardt P

En modelos animales, esa seal se asocia con formacin de nuevos vasos sanguneos y con mejores marcadores de reparacin en tejidos con irrigacin limitada como tendones y ligamentos