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Moreover, I-124 labeled cancer cell membrane-mimicking nanovesicles 124I-P/C@CMLvs loaded with multi-flavonoid VI (PPVI) and CDDP, among them the loaded PPVI promotes p53 deubiquitination and stimulates ROS production thereby triggering ferroptosis amplification mediated by GPX4 signaling and pyroptosis mediated by the NLRP3/GSDMD/Caspase-1 axis, which significantly enhances the infiltration of immune cells in tumor tissues, including DCs, CD8 + T cells and CD4 + T cells, and further promotes tumor regression when combined with anti-PD-L1 therapy (228)

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Results showed that compound 22 ( 62 ), an oxazoline DNMTi, had potent inhibitory activity against DNMT1 (IC 50 = 150 M) (Figure 10) and also exhibited a dose-dependent anti-proliferative effect against HCT116 human colon carcinoma cells

Mechanism Over Timing The peptides mechanismssuch as upregulating growth factors, improving blood flow, and supporting cellular repairsuggest a systemic effect rather than a time-sensitive one

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018

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