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Animal data provides biological plausibility and mechanistic insights but cannot guarantee human efficacy

Moreover, these can catalytically generate oxygen by ROS, and they exhibit a good hemostatic performance along with biocompatibility

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Irbesartan, an angiotensin type 1 receptor inhibitor, regulates the vascular oxidative state in patients with coronary artery disease

Consequently, BBB dysfunction can trigger neuroinflammatory responses, potentially accelerating neurodegeneration