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For material K33, in the first stage of treatment, the pathways enriched to the most metabolites were Riboflavin metabolism, D-Glutamine and D-glutamate metabolism, Purine metabolism, Phenylalanine, tyrosine and tryptophan and Arginine biosynthesis ( Figure 5D )

Subsequently, the cells in different groups were diluted to 1 10 7 cells/mL with PBS and injected into the right subcutaneous area of mice at a dose of 200 L

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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

Biochem Biophys Res Commun 418:652656 Plckthun A (2012) Ribosome display: a perspective