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Non-standard Abbreviations and Acronyms Ad- adenovirus ASCVD atherosclerotic cardiovascular disease BAT brown adipose tissue BMI body mass index CAD coronary artery disease CKM cardiovascular-kidney-metabolic EC endothelial cell ECAR extracellular acidification rate EndoMT endothelial-to-mesenchymal transition EVs extracellular vesicles eWAT epididymal white adipose tissue FACS fluorescence activated cell sorting FISH fluorescence in situ hybridization GSH glutathione HAECs human aortic endothelial cells HDL-C high-density lipoprotein cholesterol HFD high fat diet LDL-C low-density lipoprotein cholesterol LNPs lipid nanoparticles miRISCs miRNA-induced silencing complexes NTA nanoparticle tracking analysis OCR oxygen consumption rate ROC receiver operating characteristic ROS reactive oxygen species SLC7A11 solute carrier family 7 member 11 snRNA-seq single-nucleus RNA-sequencing TC total cholesterol TCA cycle tricarboxylic acid cycle TG triglycerides WAT white adipose tissue

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3-Hydroxyanthranilate dioxygenase (HAAO) oxidizes 3-hydroxyanthranilate (3-HA) to 2-amino-3-carboxymuconic semialdehyde, which is non-enzymatically cyclized to quinolinic acid

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