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Dysregulated lipid metabolism also promotes aberrant synthesis of pro-inflammatory lipid mediators such as prostaglandins and leukotrienes, thereby sustaining chronic neuroinflammatory states (Johnson and Stolzing, 2019

Relevant studies indicate that dehydroascorbate stimulates pentose phosphate pathway enzymes, increases intracellular glutathione levels, and inhibits hydrogen peroxide-induced mitochondrial transmembrane potential dissipation and cell death, highlighting its antioxidant role ( Conclusion Taoling Yuyang Decoction can improve DSS-induced colitis in mice through multiple mechanisms, including reducing oxidative stress, inhibiting inflammatory response, repairing intestinal barrier function, remodeling intestinal flora homeostasis, restoring SCFAs metabolism, and regulating fecal metabolic pathway

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The molecular docking was performed based on the CB-Dock-2 tool ( CB-Dock-2 is a protein-ligand docking method that automatically identifies binding sites, calculates the center and size, customizes the docking box size based on the query ligands, and then performs molecular docking using AutoDock Vina [17]

The GI side effects are present but manageable

Farr and Xiong, 2021)