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___ AP video journalist Javier Arciga contributed to this story from San Diego ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institutes Science and Educational Media Group and the Robert Wood Johnson Foundation

Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects

Organ-growth changes are believed to be largely irreversible, which is the strongest argument behind the 4-6 week cycle ceiling

[2] DHT is more potent than other androgenic hormones because of its high affinity to the androgen receptor

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doi: 10.1016/s0192-0561(97)00058-1