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One Protein, Multiple Phenotypes: A Concept of Neuronal Vulnerability Aside from mitochondrial dysfunction, misfolded SOD1 is implicated in the initiation and/or acceleration of numerous damaging pathways in both neurons[ 13 , 59 , 207 ] and surrounding glia, [208] including disruption of proteasome function, degradation of microtubules and microfilaments, endoplasmic reticulum stress, and redox dyshomeostasis

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However, poor glycolysis inhibits CD4 + T cell differentiation [48, 49]

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Forkhead Box M1 (FOXM1), a major transcription factor was found to be directly inhibited by TP53, which could further passively lead to inhibition of aggressive tumor cell phenotypes such as cell migration, cell proliferation and cell invasion

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Simon, A., Cobbold, S

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