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Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence

Expect 30-40% reduction in severity, which often makes the difference between barely functional and tolerably uncomfortable

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It is most effective for dehydration, deficiencies and targeted recovery

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another advantage of an on-line DAD detector is the possibility of detection of poorly ionizing compounds that cannot be detected by an MS detector, and simultaneous quantitative and qualitative analysis when the MS detector works in dynamic range modewhich results in reduction of time and cost of analysis), and a high-resolution mass spectrometer (Q-TOF, Orbitrap), especially MS/MS enabling ion fragmentation