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( F ) H&E and Sirius red staining in the liver

Iron levels and ferroptosis-related gene expression or mutations should be combined to evaluate which patients are most likely to benefit from treatment targeting ferroptosis

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The condition of overfat, which ultimately is indicative of malnutrition, adversely affects various aspects of health, including impaired innate and adaptive immune responses, promoting chronic inflammation and insulin resistance, leading to chronic diseases

For example, hepatocytes contain high levels of alpha GST and serum alpha GST has been found to be an indicator of hepatocyte injury in transplantation, toxicity and viral infections

Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes