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172 The second more generalized syndrome is characterized by mild hemolytic anemia, persistent metabolic acidosis presenting in the newborn period, and progressive cerebral and cerebellar degeneration

In murine models, intrinsic IRF5 in T cells boosts Th1 and Th17 cytokine production, suppresses Th2 cytokines, and promotes T follicular helper (Tfh) cell differentiation in vivo [5, 25, 41, 42]

10.1186/s12906-024-04532-z 93

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