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Introduction Colorectal cancer (CRC) is the second leading cause of cancer related death and the third most commonly diagnosed in the world, with 1.8 million new cases in 2018 ( MMR ) genes and in Wnt (APC) , TGFbeta/BMP signalling pathways (e.g., MADH4, SMAD4, BMPR1A ) predispose to hereditary CRC syndromes ( BMP2, BMP4, SMAD7, CCND2, GREM1 ) and in genes not previously linked to CRC (CDKN1A, EIF3H, TPD52L3, ITIH2, LAMA5, and LAMC1 ) ( Thus, the potential preventability of CRC depends on detailed understanding of its aetiology and interactive underlying mechanisms of development

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Gene identification for the cblD defect of vitamin B12 metabolism