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This intensive approach suits short-term focused treatment phases

This type of translational research seems particularly relevant to the ME/CFS field, which has long pursued evidence of neuroinflammation driven by circulating proinflammatory cytokines

4.2.15 Hederagenin Recent studies have indicated Hederagenin (HDG) can both attenuate cerebral I/R injury through the regulation of MLK3 signaling pathway (Yu et al., 2020) and enhance renal fibrosis by targeting muscarinic acetylcholine receptors (Yang and He, 2022)

It has been demonstrated that the promotion of HDAC4 phosphorylation is found after overexpression of CDKL5 via facilitating the cytoplasmic retention of HDAC4 while loss of CDKL5 leads to the decrease of HDAC4 phosphorylation, ultimately increasing the translocation of HDAC4 into the nucleus [105]

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10.1016/j.bcp.2005.11.003 Biochem